|Cartoon debut||"Muffy Gets Mature"|
|Voiced by||Elise Berstein|
She has a yellow/orange skin complexion, and she wears a white blouse with a pink shirt over it. She has black hair and a similar hairstyle as D.W.'s. She wears a pink headband in her hair. She was mean to Muffy, saying "Of course that's what you meant!" sarcastically. She is currently in a relationship with a boy named Robert.
- 510b. "Muffy Gets Mature"
- 702b. "Muffy Goes Metropolitan"
- 1003b. "The Secret About Secrets"
- 1109b. "Spoiled Rotten!"
- 1110a. "Big Brother Binky"
- 1202b. "The Frensky Family Fiasco"
- 1610b. "The Best Day Ever"
- 1802b. "Surprise!"
- 1804b. "The Tardy Tumbler"
- 1806a. "Whip. Mix. Blend."
- 2103b. "Sue Ellen & the Last Page"
- 2303b "D.W. and Dr. Whosit"