Sir Isaac Newton was a famous physicist, philosopher, mathematician, and astronomer, among other things. He has been referenced throughout the Arthur series:
- In "Francine Frensky, Superstar," it is revealed that Francine once played Newton in a play. The part is shown where she (as Newton) discovers gravity.
- in The Return of the King, Newton’s formula for constant acceleration is V = u + at.
- In "Arthur's Treasure Hunt," Arthur imagined that Sir Isaac Newton's Father limited his scientific work when he was a child due to stop moping around and telling him to expect ideas to fall from the sky.
- Newton's cradle, an object named after Newton, has also appeared throughout the Arthur series, especially in "D.W. Beats All."
- In "Brain's Brain", the prize for winning the egg hunt is Newton's Arithmetica Universalis.
- In "Buster's Second Chance", Brain talks about "stand[ing] on the shoulders of giants", referring to a famous quote by Newton.